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Prostaglandin D2 (PGD2, Cay-12010) is one of the five primary enzymatic prostaglandins derived... more
Product information "11-deoxy-11-methylene Prostaglandin D2"
Prostaglandin D2 (PGD2, Cay-12010) is one of the five primary enzymatic prostaglandins derived directly from PGH2 (Cay-17020). PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin. However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay. The CRTH2-receptor actions of 11-deoxy-11-methylene PGD2 are not yet reported.Formal Name: 9alpha,15S-dihydroxy-11-methylene-prosta-5Z,13E-dien-1-oic acid. CAS Number: 100648-29-1. Synonyms: 11-deoxy-11-methylene PGD2. Molecular Formula: C21H34O4. Formula Weight: 350.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 100 mg/ml, PBS (pH 7.2): 3.75 mg/ml. SMILES: O[C@@H](C1)[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C1=C. InChi Code: InChI=1S/C21H34O4/c1-3-4-7-10-17(22)13-14-18-16(2)15-20(23)19(18)11-8-5-6-9-12-21(24)25/h5,8,13-14,17-20,22-23H,2-4,6-7,9-12,15H2,1H3,(H,24,25)/b8-5-,14-13+/t17-,18-,19+,20-/m0/s1. InChi Key: ROZAFJXVUNORLT-SFIVEXQWSA-N.
Keywords: | 11-deoxy-11-methylene PGD2, 9alpha,15S-dihydroxy-11-methylene-prosta-5Z,13E-dien-1-oic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 12410 |
Properties
Application: | Bioactive lipid assays |
MW: | 350.5 D |
Formula: | C21H34O4 |
Purity: | >98% |
Format: | Solution |
Database Information
CAS : | 100648-29-1| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H225, H319, H333, H336, H360 |
P Phrases: | P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+312, P304+340, P305+351+338, P308+313, P312, P337+313, P370+378, P403+233, P403+235, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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