11-deoxy-11-methylene Prostaglandin D2

11-deoxy-11-methylene Prostaglandin D2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay12410-1 1 mg -

6 - 10 business days*

Cay12410-5 5 mg -

6 - 10 business days*

Cay12410-10 10 mg -

6 - 10 business days*

Prostaglandin D2 (PGD2, Cay-12010) is one of the five primary enzymatic prostaglandins derived... more
Product information "11-deoxy-11-methylene Prostaglandin D2"
Prostaglandin D2 (PGD2, Cay-12010) is one of the five primary enzymatic prostaglandins derived directly from PGH2 (Cay-17020). PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin. However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay. The CRTH2-receptor actions of 11-deoxy-11-methylene PGD2 are not yet reported. Formal Name: 9alpha,15S-dihydroxy-11-methylene-prosta-5Z,13E-dien-1-oic acid. CAS Number: 100648-29-1. Synonyms: 11-deoxy-11-methylene PGD2. Molecular Formula: C21H34O4. Formula Weight: 350.5. Purity: >98%. Formulation: A solution in methyl acetate. Solubility: DMF: 100 mg/ml, DMSO: 100 mg/ml, Ethanol: 100 mg/ml, PBS (pH 7.2): 3.75 mg/ml. SMILES: CCCCCC(O)/C=C/[C@H]1C(=C)CC(O)C1C/C=C\CCCC(=O)O. InChi Code: InChI=1S/C21H34O4/c1-3-4-7-10-17(22)13-14-18-16(2)15-20(23)19(18)11-8-5-6-9-12-21(24)25/h5,8,13-14,17-20,22-23H,2-4,6-7,9-12,15H2,1H3,(H,24,25)/b8-5-,14-13+/t17-,18-,19+,20-/m0/s1. InChi Key: ROZAFJXVUNORLT-SFIVEXQWSA-N.
Keywords: 11-deoxy-11-methylene PGD2, 9alpha,15S-dihydroxy-11-methylene-prosta-5Z,13E-dien-1-oic acid
Supplier: Cayman Chemical
Supplier-Nr: 12410


Application: Bioactive lipid assays
MW: 350.5 D
Formula: C21H34O4
Purity: >98%
Format: Solution

Database Information

CAS : 100648-29-1| Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H336, H360
P Phrases: P201, P202, P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P308+313, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
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