1-Stearoyl-2-Arachidonoyl-sn-Glycerol

1-Stearoyl-2-Arachidonoyl-sn-Glycerol
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10008650-5 5 mg -

6 - 10 business days*

50.00€
Cay10008650-10 10 mg -

6 - 10 business days*

90.00€
Cay10008650-25 25 mg -

6 - 10 business days*

203.00€
 
Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+,... more
Product information "1-Stearoyl-2-Arachidonoyl-sn-Glycerol"
Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid to phosphorylate target proteins and they initiate a variety of important signalling cascades. 1-Stearoyl-2-arachidonoyl-sn-glycerol (SAG) is a DAG that contains the omega-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. It can potently activate PKCalpha, PKCepsilon, and PKCdelta at nM concentrations. Independent of PKC signalling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T-cells. Formal Name: 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol. CAS Number: 65914-84-3. Synonyms: SAG. Molecular Formula: C41H72O5. Formula Weight: 645.0. Purity: >95%. Formulation: A solution in methyl acetate. Solubility: DMF: 0.2 mg/ml, DMSO: 0.3 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 0.1 mg/ml. SMILES: CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CO)OC(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC. InChi Code: InChI=1S/C41H72O5/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(44)46-39(37-42)38-45-40(43)35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2/h11,13,17,19,22,24,28,30,39,42H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3/b13-11-,19-17-,24-22-. InChi Key: NSXLMTYRMFVYNT-IUJDHQGTSA-N. Side Chain Carbon Sum: 38:4.
Keywords: SAG, 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycerol
Supplier: Cayman Chemical
Supplier-Nr: 10008650

Properties

Application: Bioactive lipid assays
MW: 645 D
Formula: C41H72O5
Purity: >95%
Format: Solution

Database Information

CAS : 65914-84-3| Find alternatives

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: EUH066, H225, H319, H336
P Phrases: , P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+361+353, P304+340, P305+351+338, P312, P337+313, P370+378, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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