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Soluble in DMSO or DMF. ICG is a NIR fluorescent substance which obtain license for clinical uses from US FDA (Food and Drug administration), along with Methylene Blue. It is used in Ophthalmologic angiography, liver function tests, solid tumor detection in surgical operation and angiography. Because ICG effectively absorbs near infrared wavelength that is about 800nm and its absorption ratio for wavelength of visible light range is low, noises caused by Autofluorescence is low. ICG Sulfo-NHS ester has a higher water solubility than ICG NHS ester, and it can be directly added to reacting solution without dissolving process in organic solvents such as DMSO or DMF. It is effective for labeling since it rapidly and high-specifically reacts to Protein containing amine (-NH2) in aqueous solution, Antibody and Primary amine (-NH2) of Amine-modified Oligonucleotide. Excitation ? Emission (nm): 785 / 821 nm. Extinction coefficient: 240,000 cm-1M-1. CF280: 0.05.