CpG Oligodeoxynucleotides

CpG Oligodeoxynucleotides (ODN) are small single-stranded DNA molecules containing CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG motifs are unmethylated are recognized by pattern-recognition-receptors (PRR) like Toll-like Receptor 9 (TLR9) and act as immunostimulants. CpG Oligodeoxynucleotides induce cytokine and interferon production, B-cell and monocyte maturation and the activation of NK-cells and plasmocytoid dendritic cells. CpG Oligodeoxynucleotides are therefore used as adjuvants and in cancer therapy. ODNs containing a TTAGGG-motiv however are TLR9-Antagonists and have immunosuppressive effects.

CpG Oligodeoxynucleotides (ODN) are small single-stranded DNA molecules containing CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG motifs are unmethylated are... read more »
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CpG Oligodeoxynucleotides

CpG Oligodeoxynucleotides (ODN) are small single-stranded DNA molecules containing CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG motifs are unmethylated are recognized by pattern-recognition-receptors (PRR) like Toll-like Receptor 9 (TLR9) and act as immunostimulants. CpG Oligodeoxynucleotides induce cytokine and interferon production, B-cell and monocyte maturation and the activation of NK-cells and plasmocytoid dendritic cells. CpG Oligodeoxynucleotides are therefore used as adjuvants and in cancer therapy. ODNs containing a TTAGGG-motiv however are TLR9-Antagonists and have immunosuppressive effects.

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CpG-B DNA, Rat, K-type
CpG-B DNA, Rat, K-type

Item number: C7905-83.200

The rat CpG-B DNA belongs to the class of CpG-B oligodeoxynucleotides (ODN), also known as 'K'- type ODN, with a full phosphorothioate (PS) backbone. It is particularly effective for activating B cells. The vertebrate immune system has evolved innate immune defense pattern recognition receptors (PRRs) that detect...
Application: ELISA
665.00€ *
Review
CpG-C DNA, Human, Mouse
CpG-C DNA, Human, Mouse

Item number: C7905-84.200

ODN 2395 is a prototype of the class of CpG-C oligodeoxynucleotides (ODN) and is particularly effective at activating B- and NK cells and inducing IFN-alpha production in vitro of human peripheral blood mononuclear cells (PBMC). The vertebrate immune system has evolved innate immune defense pattern recognition...
665.00€ *
Review
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