CpG Oligodeoxynucleotides

CpG oligodeoxynucleotides (ODN) are short, single-stranded DNA molecules containing a high percentage of CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG motifs are unmethylated are recognized by pattern recognition receptors (PRRs) like Toll-like receptor 9 (TLR9) and therefore act as immunostimulants. CpG oligodeoxynucleotides induce cytokine and interferon production as well as maturation and activation of B-cells, monocytes, NK-cells and plasmocytoid dendritic cells. Hence, CpG oligodeoxynucleotides are used as adjuvants and in cancer therapy. In contrast, ODNs containing a TTAGGG-motif are TLR9 antagonists and have immunosuppressive effects.

CpG oligodeoxynucleotides (ODN) are short, single-stranded DNA molecules containing a high percentage of CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG... read more »
Close window
CpG Oligodeoxynucleotides

CpG oligodeoxynucleotides (ODN) are short, single-stranded DNA molecules containing a high percentage of CpG motifs. Their backbone is partially or completely phosphothioated. ODNs whose CpG motifs are unmethylated are recognized by pattern recognition receptors (PRRs) like Toll-like receptor 9 (TLR9) and therefore act as immunostimulants. CpG oligodeoxynucleotides induce cytokine and interferon production as well as maturation and activation of B-cells, monocytes, NK-cells and plasmocytoid dendritic cells. Hence, CpG oligodeoxynucleotides are used as adjuvants and in cancer therapy. In contrast, ODNs containing a TTAGGG-motif are TLR9 antagonists and have immunosuppressive effects.

2 from 3 pages
No results were found for the filter!
ODN 2243 (Control for ODN 2216) Endotoxin-free (sterile)
ODN 2243 (Control for ODN 2216) Endotoxin-free (sterile)

Item number: IAX-200-205-C100

Negative control GpC ODN for in vivo use in rodents (50-150 µg per injection). As active compound use CpG ODN 2216 (Cat. No.: IAX-200-005). For negative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
Application: Negative Control for ODN 2216 (IAX-200-005)
MW: 6684 D
179.00€ *
Review
ODN 2137 (Control for ODN 2006) Endotoxin-free (sterile)
ODN 2137 (Control for ODN 2006) Endotoxin-free (sterile)

Item number: IAX-200-206-C100

Negative control GpC ODN for in vivo use in rodents (50-150 µg per injection). As active compound use CpG ODN 2006 (Cat. No.: IAX-200-006). For inegative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
Application: Negative Control for ODN 2006 (IAX-200-006)
MW: 6684 D
179.00€ *
Review
ODN 2395 (Type C) Endotoxin-free (sterile)
ODN 2395 (Type C) Endotoxin-free (sterile)

Item number: IAX-200-007-C100

Optimal concentration is dependent upon cell type, species, desired activation and analysis: in vitro 0.1-1 µM (~0.7-7.0 µg/ml), in vivo 50-250 µg in rodent animal models. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Keywords: CpG ODN: C Type (species: human and rodent)
Application: TLR9 activator
MW: 7068 D
From 218.00€ *
Review
iODN (inhibitory ODN) (ttaggg)4 Endotoxin-free (sterile)
iODN (inhibitory ODN) (ttaggg)4 Endotoxin-free (sterile)

Item number: IAX-200-051-C100

Potent sequence of an inhibitory ODN for in vivo use in rodents (100-300 µg per injection), prototype class II, inhibits STAT signaling, independent of TLR signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Keywords: Inhibitory ODN (iODN): Class II
Application: STAT signaling inhibitor
MW: 8288 D
From 179.00€ *
Review
Mini-iODN (inhibitory ODN) Endotoxin-free (sterile)
Mini-iODN (inhibitory ODN) Endotoxin-free (sterile)

Item number: IAX-200-053-C100

Potent sequence of an inhibitory ODN for in vivo use in rodents (50-150 µg per injection): prototype class I, may also affect TLR7 and TLR8 signaling. egative control: Neutral-ODN (Cat. No.: IAX-200-202).
Keywords: Inhibitory ODN (iODN): Class I
Application: TLR9 competitor
MW: 3584 D
179.00€ *
Review
Mega-iODN (inhibitory ODN) Endotoxin-free (sterile)
Mega-iODN (inhibitory ODN) Endotoxin-free (sterile)

Item number: IAX-200-054-C100

Particularly potent sequence of an inhibitory ODN for in vivo use in rodents (50-150µg per injection): based on class I (ODN H154) and class II (ODN A151) sequences to combine inhibitory activity on TLRs and STAT signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Keywords: Inhibitory ODN (iODN): Class I/II
Application: TLR9 competitor
MW: 5894 D
179.00€ *
Review
Duo-iODN (inhibitory ODN) Endotoxin-free (sterile)
Duo-iODN (inhibitory ODN) Endotoxin-free (sterile)

Item number: IAX-200-055-C100

Potent sequence of an inhibitory ODN for in vivo use in rodents (50-150µg per injection): prototype class I that also inhibits TLR7 signaling. Negative control: Neutral-ODN (Cat. No.: IAX-200-202).
Keywords: Inhibitory ODN (iODN): Class I
Application: TLR9 competitor
MW: 5867 D
From 179.00€ *
Review
ODN 2218 (Control for ODN 1585) Endotoxin-free (sterile)
ODN 2218 (Control for ODN 1585) Endotoxin-free (sterile)

Item number: IAX-200-203-C100

Negative control GpC ODN for in vivo use in rodents (50-150 µg per injection). As active compound use CpG ODN M362 (Cat. No.: IAX-200-004). For negative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
Application: Negative Control for ODN M362 (IAX-200-004)
MW: 8073 D
179.00€ *
Review
ODN M383 (Control for ODN M362) Endotoxin-free (sterile)
ODN M383 (Control for ODN M362) Endotoxin-free (sterile)

Item number: IAX-200-204-C100

Negative control GpC ODN for in vivo use in rodents (50-150 µg per injection). As active compound use CpG ODN 2216 (Cat. No.: IAX-200-005). For negative control without agonistic nor antagonistic activity: Neutral-ODN (Cat. No.: IAX-200-202).
Application: Negative Control for ODN 2216 (IAX-200-005)
MW: 8073 D
179.00€ *
Review
CpG-A DNA, ODN 2216 Prototype
CpG-A DNA, ODN 2216 Prototype

Item number: C7905-80.200

ODN 2216 is a prototype of the class of CpG-A oligodeoxynucleotides (ODN), also known as 'D'-type ODN, and contains a phosphodiester (PO) backbone. It is particularly effective for activating NK cells and inducing IFN-alpha production in plasmacytoid dendritic cell (PDC) precursors. The vertebrate immune system has...
Application: ELISA
939.00€ *
Review
CpG-B DNA, Rabbit
CpG-B DNA, Rabbit

Item number: C7905-81.200

ODN 2007 is a prototype of CpG oligodeoxynucleotides (ODN) that is able to stimulate rabbit PBMC in vitro. The vertebrate immune system has evolved innate immune defense pattern recognition receptors (PRRs) that detect unmethylated cytosine-phosphate-guanine (CpG) motifs within bacterial DNA. Cellular activation by...
Application: ELISA
939.00€ *
Review
CpG-B DNA, Human, Mouse, K-type
CpG-B DNA, Human, Mouse, K-type

Item number: C7905-82.200

ODN 2006 is a prototype of the class of CpG-B oligodeoxynucleotides (ODN), also known as 'K'-type ODN, with a full phosphorothioate (PS) backbone. It is particularly effective for activating B cells.The vertebrate immune system has evolved innate immune defense pattern recognition receptors (PRRs) that detect...
Application: ELISA
939.00€ *
Review
2 from 3 pages