Wiskostatin

Wiskott-Aldrich syndrome proteins (WASPs) regulate the actin cytoskeleton by directly interacting with actin in the Arp2/3 complex. As a result, they have essential functions in diverse cellular processes, including phagocytosis, cell motility, and membrane trafficking. Wiskostatin is a cell-permeable, selective inhibitor of neural WASP (N-WASP, IC50 = ~10 µM). It directly associates with the GTPase-binding domain of N-WASP, preventing its activation by Cdc42 and phosphatidylinositol 4,5-bisphosphate. By inhibiting N-WASP, wiskostatin interferes with membrane transport, endocytosis, and neurological development.Formal Name: 3,6-dibromo-alpha-[(dimethylamino)methyl]-9H-carbazole-9-ethanol. CAS Number: 253449-04-6. Molecular Formula: C17H18Br2N2O. Formula Weight: 426.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 234, 241, 271, 303, 344, 359 nm. SMILES: OC(CN(C)C)CN1C2=CC=C(Br)C=C2C3=C1C=CC(Br)=C3. InChi Code: InChI=1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3. InChi Key: XUBJEDZHBUPBKL-UHFFFAOYSA-N.