Wee1 Inhibitor

Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50 = 11 nM). It is selective for Wee1 over checkpoint kinase 1 (Chk1, IC50 = 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50 = 25 µM for the E. coli enzyme).Formal Name: 4-(2-chlorophenyl)-9-hydroxy-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione. CAS Number: 622855-37-2. Molecular Formula: C20H11ClN2O3. Formula Weight: 362.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mg/ml, Ethanol: 10 mg/ml. SMILES: OC1=CC=C(N([H])C2=C3C4=C(C(N([H])C4=O)=O)C(C5=C(Cl)C=CC=C5)=C2)C3=C1. InChi Code: InChI=1S/C20H11ClN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26). InChi Key: DPEXRCOBPACFOO-UHFFFAOYSA-N.