Item number Size Datasheet Manual SDS Delivery time Quantity Price
SYN-3006-M005 5 mg -

3 - 9 business days*

SYN-3006-M010 10 mg -

3 - 9 business days*

SYN-3006-M050 50 mg -

3 - 9 business days*

SYN-3006-M100 100 mg -

3 - 9 business days*

Solid. Soluble in DMSO or ethanol. Almost insoluble in water. Vorinostat (SAHA, MK0683, Zolinza)... more
Product information "Vorinostat"
Solid. Soluble in DMSO or ethanol. Almost insoluble in water. Vorinostat (SAHA, MK0683, Zolinza) inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50< 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine residues of histones proteins. In some cancer cells, there is an overexpression of HDACs, or an aberrant recruitment of HDACs to oncogenic transcription factors causing hypoacetylation of core nucleosomal histones. By inhibiting histone deacetylase, vorinostat causes the accumulation of acetylated histones and induces cell cycle arrest and/or apoptosis of some transformed cells. The mechanism of the antineoplastic effect of vorinostat has not been fully characterized.
Keywords: SAHA, MK0683, Zolinza
Supplier: SYNkinase
Supplier-Nr: 3006


Application: HDAC inhibitor
MW: 264,3 D
Formula: C14H20N2O3
Purity: >95%
Format: Solid

Database Information

CAS : 149647-78-9| Find alternatives
KEGG ID : K06067 | Find alternatives

Handling & Safety

Storage: +4°C
Shipping: +20°C (International: +20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301, H312, H315, H317, H318, H331, H335, H341, H360, H373
P Phrases: P201, P261, P280, P311, P301+P310, P305+P351+P338
Our products are for laboratory research use only: Not for administration to humans!
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