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U-73122 (Cay-70740) is an inhibitor of PLC-dependent processes, however, the mechanism of action remains unclear. The IC50 values for inhibition of platelet aggregation induced by collagen or thrombin are 0.6 and 5 µM, respectively. It also exhibits inhibitory activity against HIV-1 integrase with an IC50 value of 7 µM. U-73343 is a close structural analog of U-73122 that does not inhibit PLC, making it useful as a negative control for PLC inhibition.Formal Name: 1-[6-[[(17b)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione. CAS Number: 142878-12-4. Molecular Formula: C29H42N2O3. Formula Weight: 466.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 0.5 mg/ml, Ethanol: 0.25 mg/ml. SMILES: COC1=CC=C2C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4NCCCCCCN5C(CCC5=O)=O)=C1. InChi Code: InChI=1S/C29H42N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,19,23-26,30H,3-7,9,11-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1. InChi Key: CJHWFIUASFBCKN-ZRJUGLEFSA-N.
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