Trimidox (hydrochloride)

Trimidox (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10011124-5 5 mg -

6 - 10 business days*

64.00€
Cay10011124-10 10 mg -

6 - 10 business days*

122.00€
Cay10011124-25 25 mg -

6 - 10 business days*

288.00€
Cay10011124-50 50 mg -

6 - 10 business days*

510.00€
 
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target... more
Product information "Trimidox (hydrochloride)"
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM. Formal Name: N,3,4,5-tetrahydroxy-benzenecarboximidamide, monohydrochloride. CAS Number: 95933-75-8. Synonyms: CF 233 (hydrochloride). Molecular Formula: C7H8N2O4 . HCl. Formula Weight: 220.6. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 2 mg/ml, Ethanol: 0.25 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 220, 280 nm. SMILES: Cl.ONC(=N)c1cc(O)c(O)c(O)c1. InChi Code: InChI=1S/C7H8N2O4.ClH/c8-7(9-13)3-1-4(10)6(12)5(11)2-3,/h1-2,10-13H,(H2,8,9),1H. InChi Key: KBKNXSNOQYLIRI-UHFFFAOYSA-N.
Keywords: CF 233 (hydrochloride), N,3,4,5-tetrahydroxy-benzenecarboximidamide, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 10011124

Properties

Application: Ribonucleotide reductase inhibitor
MW: 220.6 D
Formula: C7H8N2O4 . HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 95933-75-8| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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