Trimidox (hydrochloride)

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.Formal Name: N,3,4,5-tetrahydroxy-benzenecarboximidamide, monohydrochloride. CAS Number: 95933-75-8. Synonyms: CF 233 (hydrochloride). Molecular Formula: C7H8N2O4 . HCl. Formula Weight: 220.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 2 mg/ml, Ethanol: 0.25 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 220, 280 nm. SMILES: Cl.ONC(=N)c1cc(O)c(O)c(O)c1. InChi Code: InChI=1S/C7H8N2O4.ClH/c8-7(9-13)3-1-4(10)6(12)5(11)2-3,/h1-2,10-13H,(H2,8,9),1H. InChi Key: KBKNXSNOQYLIRI-UHFFFAOYSA-N.