Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10009083-5 5 mg -

6 - 10 business days*

Cay10009083-10 10 mg -

6 - 10 business days*

Cay10009083-50 50 mg -

6 - 10 business days*

Cay10009083-100 100 mg -

6 - 10 business days*

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target... more
Product information "Trimidox"
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM. Formal Name: N,3,4,5-tetrahydroxy-benzenecarboximidamide. CAS Number: 95933-74-7. Synonyms: VF 233. Molecular Formula: C7H8N2O4. Formula Weight: 184.2. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2)(1:2): 0.3 mg/ml. lambdamax: 214, 261 nm. SMILES: OC1=C(O)C(O)=CC(C(NO)=N)=C1. InChi Code: InChI=1S/C7H8N2O4/c8-7(9-13)3-1-4(10)6(12)5(11)2-3/h1-2,10-13H,(H2,8,9). InChi Key: MSLJYSGFUMYUDX-UHFFFAOYSA-N.
Keywords: VF 233, N,3,4,5-tetrahydroxy-benzenecarboximidamide
Supplier: Cayman Chemical
Supplier-Nr: 10009083


Application: Ribonucleotide reductase inhibitor
MW: 184.2 D
Formula: C7H8N2O4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 95933-74-7| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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