Triciribine

Triciribine
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010237-1 1 mg -

6 - 10 business days*

147.00€
Cay10010237-5 5 mg -

6 - 10 business days*

659.00€
Cay10010237-10 10 mg -

6 - 10 business days*

1,170.00€
 
Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase... more
Product information "Triciribine"
Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 µM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Formal Name: 1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-1,2,5,6,8-pentaazaacenaphthylen-3-amine. CAS Number: 35943-35-2. Synonyms: API 2, NSC 154020, Tricyclic Nucleoside. Molecular Formula: C13H16N6O4. Formula Weight: 320.3. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 0.5 mg/ml. lambdamax: 295 nm. SMILES: OC[C@H]1O[C@H](C(O)C1O)n1cc2c(N)nn(C)c3ncnc1c23. InChi Code: InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1. InChi Key: HOGVTUZUJGHKPL-HTVVRFAVSA-N.
Keywords: API 2, NSC 154020, Tricyclic Nucleoside, 1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-1,2,5,6,8-pentaazaacenaphthylen-3-amine
Supplier: Cayman Chemical
Supplier-Nr: 10010237

Properties

Application: Akt inhibitor
MW: 320.3 D
Formula: C13H16N6O4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 35943-35-2| Find alternatives
KEGG ID : K04456 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H350
P Phrases: P201, P202, P280, P308+313, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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