Trichostatin C

Trichostatin C is a glycosylated derivative of trichostatin A (Cay-89730), the antifungal antibiotic that reversibly inhibits histone deacetylase. Trichostatin C is reported to be the first example of a glucopyranosyl hydroxamate identified in nature. It has been shown to induce the differentiation of a mouse erythroleukemia cell line and to increase histone H4 acetylation in B cells, though at higher concentrations than trichostatin A.Formal Name: (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-(beta-D-glucopyranosyloxy)-4,6-dimethyl-7-oxo-2,4-heptadienamide. CAS Number: 68676-88-0. Synonyms: Antibiotic 145-A. Molecular Formula: C23H32N2O8. Formula Weight: 464.5. Purity: >95%. Formulation: (Request formulation change), A powder. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: CN(C)C1=CC=C(C([C@H](C)/C=C(C)/C=C/C(NO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)=O)=O)C=C1. InChi Code: InChI=1S/C23H32N2O8/c1-13(11-14(2)19(28)15-6-8-16(9-7-15)25(3)4)5-10-18(27)24-33-23-22(31)21(30)20(29)17(12-26)32-23/h5-11,14,17,20-23,26,29-31H,12H2,1-4H3,(H,24,27)/b10-5+,13-11+/t14-,17-,20-,21+,22-,23+/m1/s1. InChi Key: YECWTLGLNDDPGE-PIFXLSLCSA-N.