TLR4-C34

TLR4-C34
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay18512-5 5 mg -

6 - 10 business days*

98.00€
Cay18512-10 10 mg -

6 - 10 business days*

147.00€
Cay18512-25 25 mg -

6 - 10 business days*

339.00€
Cay18512-50 50 mg -

6 - 10 business days*

628.00€
 
Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), with LPS-binding protein,... more
Product information "TLR4-C34"
Toll-like receptor 4 (TLR4) is activated by lipopolysaccharide (LPS), with LPS-binding protein, to initiate an innate immune response, which typically includes increased expression of TNFalpha. TLR4-C34 is a 2-acetamidopyranoside that inhibits TLR4 signaling in enterocytes and macrophages in vitro when used at 10 µM. It does not affect signaling through either TLR2 or TLR9. TLR4-C34, used at 1 mg/kg in vivo, also reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. It markedly decreases the basal expression of TNFalpha, as well as LPS-induced iNOS and TNFalpha expression, in intestinal tissue isolated from patients with necrotizing enterocolitis.Formal Name: 1-methylethyl 2-(acetylamino)-2-deoxy-alpha-D-glucopyranoside, 3,4,6-triacetate. CAS Number: 40592-88-9. Synonyms: C34, TLR4-IN-C34, Toll-Like Receptor 4-C34. Molecular Formula: C17H27NO9. Formula Weight: 389.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 25 mg/ml, Ethanol: 50 mg/ml, PBS (pH 7.2): 3 mg/ml. SMILES: CC(O[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1NC(C)=O)OC(C)=O)OC(C)=O)COC(C)=O)C. InChi Code: InChI=1S/C17H27NO9/c1-8(2)24-17-14(18-9(3)19)16(26-12(6)22)15(25-11(5)21)13(27-17)7-23-10(4)20/h8,13-17H,7H2,1-6H3,(H,18,19)/t13-,14-,15-,16-,17+/m1/s1. InChi Key: KMIQMFHPUJUDMC-HHARLNAUSA-N.
Keywords: C34, TLR4-IN-C34, Toll-Like Receptor 4-C34, 1-methylethyl 2-(acetylamino)-2-deoxy-alpha-D-glucopyranoside, 3,4,6-triacetate
Supplier: Cayman Chemical
Supplier-Nr: 18512

Properties

Application: TLR4 signaling inhibitor
MW: 389.4 D
Formula: C17H27NO9
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 40592-88-9| Matching products
KEGG ID : K10160 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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