Tizoxanide

Tizoxanide is an active metabolite of the antiparasitic nitazoxanide (Cay-13692). Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 µg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC50s = 6.2 and 17.5 µM, respectively), inhibits influenza A replication (EC50s = 0.3-1 µM), and inhibits hepatitis B and hepatitis C virus replication (EC50 = 0.15 µM for both).Formal Name: 2-hydroxy-N-(5-nitro-2-thiazolyl)-benzamide. CAS Number: 173903-47-4. Synonyms: NSC 697856. Molecular Formula: C10H7N3O4S. Formula Weight: 265.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 5 mg/ml. SMILES: OC1=C(C(NC2=NC=C([N+]([O-])=O)S2)=O)C=CC=C1. InChi Code: InChI=1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15). InChi Key: FDTZUTSGGSRHQF-UHFFFAOYSA-N.