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Sulindac is a non-steroidal anti-inflammatory drug (NSAID), a COX-2 inhibitor (IC50 = 0.79 µM),... more
Product information "Sulindac"
Sulindac is a non-steroidal anti-inflammatory drug (NSAID), a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of the COX inhibitor sulindac sulfide (Cay-10004387). It is selective for COX-2 over COX-1 (IC50 = >1,000 µM). It inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats when administered at a dose of 100 mg/kg. Sulindac (60 mg/kg) reduces tumor growth in a BxPC-3 pancreatic cancer mouse xenograft model. Formulations containing sulindac have been used in the treatment of pain and inflammation associated with arthritis.Formal Name: 5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid. CAS Number: 38194-50-2. Molecular Formula: C20H17FO3S. Formula Weight: 356.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:5): .15 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): .05 mg/ml. lambdamax: 226, 258, 286, 329 nm. SMILES: FC1=CC=C(/C(C(C)=C2CC(O)=O)=C\C3=CC=C(S(C)=O)C=C3)C2=C1. InChi Code: InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-. InChi Key: MLKXDPUZXIRXEP-MFOYZWKCSA-N. Origin: Synthetic.
Keywords: | 5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10004386 |
Properties
Application: | COX inhibitor |
MW: | 356.4 D |
Formula: | C20H17FO3S |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 38194-50-2| Matching products |
KEGG ID : | K11987 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H301, H317, H334, H361 |
P Phrases: | P201, P202, P261, P264, P270, P272, P280, P284, P321, P330, P301+P310, P302+P352, P304+P341, P308+P313, P333+P313, P342+P311, P362+P364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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