Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10004386-1000 1 g -

6 - 10 business days*

Cay10004386-5000 5 g -

6 - 10 business days*

Cay10004386-10000 10 g -

6 - 10 business days*

Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of... more
Product information "Sulindac"
Many non-steroidal anti-inflammatory drugs (NSAIDs) are potent but non-selective inhibitors of both COX-1 and COX-2 in humans. Sulindac is one of the older NSAIDs, an isostere of indomethacin developed before the inducible form of COX-2 was discovered. Although a number of NSAIDs have been found to protect against digestive tract cancers, sulindac has an extensive epidemiology documenting reduced human colorectal cancer. In murine models, sulindac was found not only to inhibit the enzymatic activity of polyp-associated COX-2, but also to downregulate the expression of colonic COX-2 protein to control levels. Formal Name: 5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid. CAS Number: 38194-50-2. Molecular Formula: C20H17FO3S. Formula Weight: 356.4. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:5): .15 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): .05 mg/ml. lambdamax: 226, 258, 286, 329 nm. SMILES: FC1=CC=C(/C(C(C)=C2CC(O)=O)=C\C3=CC=C(S(C)=O)C=C3)C2=C1. InChi Code: InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-. InChi Key: MLKXDPUZXIRXEP-MFOYZWKCSA-N. Origin: Synthetic.
Keywords: 5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
Supplier: Cayman Chemical
Supplier-Nr: 10004386


Application: COX inhibitor
MW: 356.4 D
Formula: C20H17FO3S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 38194-50-2| Find alternatives
KEGG ID : K11987 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301, H317, H334, H361
P Phrases: P201, P202, P261, P264, P270, P272, P280, P284, P301+310, P302+352, P304+341, P308+313, P321, P330, P333+313, P342+311, P362+364, P405, P501
Our products are for laboratory research use only: Not for administration to humans!
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