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STO-609 is a calcium/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor (IC50s = 120 and 40 ng/ml for CaMKKalpha and CaMKKbeta, respectively). It is selective for CaMKKs over CaMKI, CaMKII, CaMKIV, MLCK, PKC, PKA, and p42 MAPK (IC50s = > 10,000 ng/ml for all). STO-609 inhibits phosphorylation of CaMKI and AMP-activated protein kinase (AMPK) in chicken sperm in the presence of extracellular calcium, as well as reduces chicken sperm motility, in a concentration-dependent manner. It decreases hypothalamic neuropeptide Y (Npy) and agouti-related protein (Agrp) expression and cumulative food intake in mice when administered intracerebroventricularly as a 20 µM solution at a continuous rate of 0.5 µL/hour. STO-609 (3 µg/animal, i.c.v.) increases cortical, striatal, and total infarct volume in a mouse model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO).Formal Name: 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, monoacetate. CAS Number: 1173022-21-3. Molecular Formula: C19H10N2O3 . C2H4O2. Formula Weight: 374.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: 100 mM NaOH: 10 mg/ml, DMSO: 1 mg/ml. lambdamax: 220, 287, 298, 389 nm. SMILES: O=C(N1C2=NC3=C1C=CC=C3)C4=C(C2=CC=C5C(O)=O)C5=CC=C4.CC(O)=O. InChi Code: InChI=1S/C19H10N2O3.C2H4O2/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18,1-2(3)4/h1-9H,(H,23,24),1H3,(H,3,4). InChi Key: WNRSTFUVBWNELX-UHFFFAOYSA-N.
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