Simvastatin

Simvastatin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010344-5 5 mg -

6 - 10 business days*

43.00€
Cay10010344-25 25 mg -

6 - 10 business days*

77.00€
Cay10010344-50 50 mg -

6 - 10 business days*

114.00€
Cay10010344-100 100 mg -

6 - 10 business days*

179.00€
 
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces... more
Product information "Simvastatin"
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid leukemia cells. It also inhibits glutathione peroxidase 4 (GPX4) activity, increases malondialdehyde (MDA) levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells. Formulations containing simvastatin have been used in the treatment of dyslipidemias.Formal Name: 2,2-dimethyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid. CAS Number: 79902-63-9. Synonyms: MK-733, SVA. Molecular Formula: C25H38O5. Formula Weight: 418.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 238 nm. SMILES: C[C@H]1C=CC2=C[C@H](C)C[C@H](OC(C(C)(C)CC)=O)C2[C@H]1CC[C@@H]3C[C@@H](O)CC(O3)=O. InChi Code: InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23?/m0/s1. InChi Key: RYMZZMVNJRMUDD-OVOOIQHOSA-N.
Keywords: MK-733, 2,2-dimethyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid
Supplier: Cayman Chemical
Supplier-Nr: 10010344

Properties

Application: HMG-CoA reductase inhibitor
MW: 418.6 D
Formula: C25H38O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 79902-63-9| Matching products
KEGG ID : K00021 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H303, H315, H362, H400, H410
P Phrases: P201, P260, P263, P264, P270, P273, P280, P302+352, P308+313, P312, P321, P332+313, P362+364, P391, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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