SGC6870

SGC6870 is an inhibitor of protein arginine methyltransferase 6 (PRMT6, IC50 = 77 nM). It is selective for PRMT6 over a panel of 76 methyltransferases, G protein-coupled receptors (GPCRs), ion channels, receptors, and other enzymes at 1 µM. SGC6870 decreases the levels of dimethylated arginine 2 on histone 3 (H3R2me2) and dimethylated arginine 3 on histone 4 (H4R3me2) in HEK293T cells (IC50s = 0.9 and 0.6 µM, respectively). See the Structural Genomics Consortium (SGC) website for more information.Formal Name: 4-[(5R-bromo-2-thienyl)carbonyl]-5-(3,5-dimethylphenyl)-1,3,4,5-tetrahydro-7-methyl-2H-1,4-benzodiazepin-2-one. CAS Number: 2561471-27-8. Molecular Formula: C23H21BrN2O2S. Formula Weight: 469.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: Soluble. SMILES: CC1=CC=C2C([C@](C3=CC(C)=CC(C)=C3)([H])N(C(C4=CC=C(Br)S4)=O)CC(N2)=O)=C1. InChi Code: InChI=1S/C23H21BrN2O2S/c1-13-4-5-18-17(11-13)22(16-9-14(2)8-15(3)10-16)26(12-21(27)25-18)23(28)19-6-7-20(24)29-19/h4-11,22H,12H2,1-3H3,(H,25,27)/t22-/m1/s1. InChi Key: NIPTUMFVYBXSMZ-JOCHJYFZSA-N.