(S)-MG132

(S)-MG132
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10012628-1 1 mg -

6 - 10 business days*

27.00€
Cay10012628-5 5 mg -

6 - 10 business days*

84.00€
Cay10012628-10 10 mg -

6 - 10 business days*

100.00€
Cay10012628-50 50 mg -

6 - 10 business days*

369.00€
 
The ubiquitin-proteasome pathway plays an integral role in the selective degradation of... more
Product information "(S)-MG132"
The ubiquitin-proteasome pathway plays an integral role in the selective degradation of intracellular proteins. While important for clearing damaged or misfolded proteins, this proteolytic pathway also regulates the availability of key proteins involved in the control of inflammatory processes, cell cycle regulation, and gene expression. (S)-MG132 is a potent, reversible and cell permeable proteasome inhibitor that inhibits cell growth in B16 and IPC227F cells with IC50 values of 42 and 77 nM, respectively. (S)-MG132 at 10 µM inhibits NF-kappaB activation, sensitizing a variety of carcinoma cell lines to apoptosis.Formal Name: N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide. CAS Number: 133407-82-6. Synonyms: Z-Leu-Leu-Leu-CHO. Molecular Formula: C26H41N3O5. Formula Weight: 475.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 25 mg/ml. SMILES: O=C[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1. InChi Code: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1. InChi Key: TZYWCYJVHRLUCT-VABKMULXSA-N.
Keywords: Z-Leu-Leu-Leu-CHO, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide
Supplier: Cayman Chemical
Supplier-Nr: 10012628

Properties

Application: Proteasome inhibitor
MW: 475.6 D
Formula: C26H41N3O5
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 133407-82-6| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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