S-Benzoylthiamine O-monophosphate

S-Benzoylthiamine O-monophosphate
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CDX-B0403-G001 1 g - -

3 - 9 business days*

91.00€
CDX-B0403-G005 5 g - -

3 - 9 business days*

337.00€
 
S-Benzoylthiamine O-monophosphate is a lipid-soluble form of vitamin B1 (thiamine).... more
Product information "S-Benzoylthiamine O-monophosphate"
S-Benzoylthiamine O-monophosphate is a lipid-soluble form of vitamin B1 (thiamine). S-Benzoylthiamine O-monophosphate facilitates the action of thiamine diphosphate, a cofactor for the enzyme transketolase. The activation of transketolase enzyme accelerates the precursors of advanced glycation end products (AGEs) towards the pentose phosphate pathway thereby reducing the production of AGEs. The reduction in AGEs subsequently decreases metabolic stress which benefits vascular complications seen in diabetes. The anti-AGE property of S-Benzoylthiamine O-monophosphate certainly makes it effective for the treatment of diabetic neuropathy, nephropathy and retinopathy. S-Benzoylthiamine O-monophosphate appears to have a also cardioprotective role in potentiating angiogenesis and inhibiting apoptosis in diabetic complications. S-Benzoylthiamine O-monophosphate also modulates pathways such as arachidonic acid (AA), nuclear transcription Factor kappaB (NF-kappaB), protein kinase B, mitogen-activated protein kinases (MAPK) and vascular endothelial growth factor receptor 2 (VEGFR2) signaling pathways, which are also responsible for it's anti-inflammatory and anti-tumor properties. S-Benzoylthiamine O-monophosphate has been shown to be a dual inhibitory action on COX-2 and LOX-5, supressing PKC and NF-kappaB activation, preventing the downregulation of PKB/Akt during diabetic complications and enhancing cell survival, regulating GSK-3 activity through Akt (rendering it's anti-AD activity) and inducing cell death through paraptosis. Product References: (1) E. Beltramo, et al., Acta Diabetol. 45, 131 (2008) , (2) P. Balakumar, et al., Pharmacol. Res. 61, 482 (2010) , (3) V. Raj, et al., Eur. Rev. Med. Pharmacol. Sci. 22, 3261 (2018) (Review) Appearance: White to off-white powder. Solubility: Slightly soluble in DMSO (1mg/ml). Identity: Determined by 1H-NMR. InChi Key: BTNNPSLJPBRMLZ-GHRIWEEISA-N Smiles: CC1=NC(N)=C(CN(/C(C)=C(CCOP(O)(O)=O)/SC(C2=CC=CC=C2)=O)C=O)C=N1
Keywords: Benfotiamine, Benzoylthiamine monophosphate
Supplier: Chemodex
Supplier-Nr: B0403

Properties

Application: Lipid-soluble vitamin B1 (thiamine) form
MW: 466.45 D
Formula: C19H23N4O6PS
Purity: >98% (HPLC)
Format: Solid

Database Information

CAS : 22457-89-2| Matching products

Handling & Safety

Storage: +4°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "S-Benzoylthiamine O-monophosphate"
Write a review
or to review a product.
Viewed