S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)

S-(5'-Adenosyl)-L-methionine chloride (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases. The transfer of a methyl group from SAM to an acceptor produces S-adenosyl-L-homocysteine (Cay-13603). SAM is also metabolized by SAM decarboxlase to give decarboxylated SAM, which is involved in the polyamine pathway that generates spermine. Cayman Chemical's SAM has been purified to remove all S-adenosylhomocysteine, a known inhibitor of most SAM-dependent methyltransferases which is commonly found in other commercially available SAM. In addition, Cayman's SAM contains no S-methylthioadenosine, a common impurity which may act as a substrate in some assay formats, resulting in high background.Formal Name: 5'-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine, dihydrochloride. CAS Number: 86867-01-8. Synonyms: AdoMet, SAM, SAMe. Molecular Formula: C15H23ClN6O5S . 2HCl. Formula Weight: 507.8. Purity: >95%. Formulation: (Request formulation change), A lyophilized powder. Solubility: Methanol: 1 mg/ml, Water: 5 mg/ml. SMILES: NC1=C2C(N([C@@H]3O[C@H](C[S+](CC[C@H](N)C(O)=O)C)[C@@H](O)[C@H]3O)C=N2)=NC=N1.[Cl-].Cl.Cl. InChi Code: InChI=1S/C15H22N6O5S.3ClH/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21,,,/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25),3*1H/t7-,8+,10+,11+,14+,27?,,,/m0.../s1. InChi Key: KBAFOJZCBYWKPU-XQVUROGGSA-N.