Rosiglitazone

Rosiglitazone
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay71740-10 10 mg -

6 - 10 business days*

32.00€
Cay71740-25 25 mg -

6 - 10 business days*

63.00€
Cay71740-50 50 mg -

6 - 10 business days*

110.00€
Cay71740-100 100 mg -

6 - 10 business days*

188.00€
 
Rosiglitazone is a thiazolidinedione agonist of peroxisome proliferator-activated receptor gamma... more
Product information "Rosiglitazone"
Rosiglitazone is a thiazolidinedione agonist of peroxisome proliferator-activated receptor gamma (PPARgamma) that binds to the ligand binding domain (LBD) of PPARgamma with a Kd value of 43 nM. It selectively activates chimeras containing the LBDs of PPARgamma over PPARalpha and PPARdelta in a cell-based reporter assay when used at a concentration of 10 mM. Rosiglitazone also activates full-length PPARgamma1 and PPARgamma2 in a reporter assay (EC50s = 30 and 100 nM, respectively). It induces differentiation of C3H10T1/2 stem cells to adipocytes when used at a concentration of 1 µM. Rosiglitazone (4 mg/kg) decreases hemoglobin A1c (HbA1c) and fasting blood glucose levels in a rat model of type 2 diabetes induced by streptozotocin (STZ, Cay-13104) and a high-carbohydrate/high-fat diet. It also inhibits increases in contusion volume, macrophage infiltration and activation of microglia, and expression of IL-6, MCP1, ICAM1, caspase-3, and Bax in mouse cerebral cortex in a model of traumatic brain injury induced by controlled cortical impact when administered at a dose of 6 mg/kg. Formulations containing rosiglitazone have been used to improve glycemic control in the treatment of type 2 diabetes. Formal Name: 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione. CAS Number: 122320-73-4. Synonyms: BRL 49653. Molecular Formula: C18H19N3O3S. Formula Weight: 357.4. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 34 mg/ml, DMSO:PBS (7.2 pH) (1:3): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 248, 311 nm. SMILES: O=C1NC(=O)C(S1)Cc1ccc(OCCN(C)c2ccccn2)cc1. InChi Code: InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23). InChi Key: YASAKCUCGLMORW-UHFFFAOYSA-N.
Keywords: BRL 49653, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Supplier: Cayman Chemical
Supplier-Nr: 71740

Properties

Application: PPARgamma agonist
MW: 357.4 D
Formula: C18H19N3O3S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 122320-73-4| Find alternatives
KEGG ID : K08530 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H319, H361, H410
P Phrases: P201, P202, P264, P273, P280, P305+351+338, P308+313, P337+313, P391, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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