RGFP109

RGFP109 is a brain-penetrant inhibitor of histone deacetylases (HDACs, IC50s = 60 and 50 nM, Kis = 32 and 5 nM for HDAC1 and HDAC3 in cell-free assays, respectively). It has been shown to upregulate frataxin mRNA levels in cultured cells obtained from Friedreich's ataxia patients and in a GAA repeat-based mouse model of Friedreich's ataxia.Formal Name: N-[6-[(2-aminophenyl)amino]-6-oxohexyl]-4-methyl-benzamide. CAS Number: 1215493-56-3. Synonyms: RG-2833. Molecular Formula: C20H25N3O2. Formula Weight: 339.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:6): 0.14mg/ml, DMSO: 20 mg/ml, Ethanol: 1.67 mg/ml. lambdamax: 290 nm. SMILES: NC1=C(NC(CCCCCNC(C2=CC=C(C)C=C2)=O)=O)C=CC=C1. InChi Code: InChI=1S/C20H25N3O2/c1-15-10-12-16(13-11-15)20(25)22-14-6-2-3-9-19(24)23-18-8-5-4-7-17(18)21/h4-5,7-8,10-13H,2-3,6,9,14,21H2,1H3,(H,22,25)(H,23,24). InChi Key: VOPDXHFYDJAYNS-UHFFFAOYSA-N.