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RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol (Cay-15043). It inhibits glutamate-induced cell death in HT22 cells (IC50 = 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 µM. RC574 (3 µM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells when used at concentrations ranging from 62.5 to 1,000 nM.Formal Name: 2,6-bis(1,1-dimethylethyl)-4-(2-thienylseleno)-phenol. CAS Number: 2584411-87-8. Molecular Formula: C18H24OSSe. Formula Weight: 367.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 239 nm. SMILES: OC1=C(C(C)(C)C)C=C([Se]C2=CC=CS2)C=C1C(C)(C)C. InChi Code: InChI=1S/C18H24OSSe/c1-17(2,3)13-10-12(21-15-8-7-9-20-15)11-14(16(13)19)18(4,5)6/h7-11,19H,1-6H3. InChi Key: CUSKUKDTRDQWBN-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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