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(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen (Cay-70250) that has diverse biological activities. It inhibits gamma-secretase activity in vitro and, in vivo, it reduces formation of amyloid-beta peptide 1-42 (Abeta42) and improves axonal transport in young Abeta-plaque free mice but not old mice with existing Abeta plaques in the Tg2576 transgenic model of Alzheimer's disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-kappaB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.