Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay70255-100 100 mg -

1 - 10 business days

Cay70255-250 250 mg -

1 - 10 business days

Cay70255-500 500 mg -

1 - 10 business days

Cay70255-1 1 g -

1 - 10 business days

(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor... more
Product information "(R)-Flurbiprofen"
(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen (Cay-70250) that has diverse biological activities. It inhibits gamma-secretase activity in vitro and, in vivo, it reduces formation of amyloid-beta peptide 1-42 (Abeta42) and improves axonal transport in young Abeta-plaque free mice but not old mice with existing Abeta plaques in the Tg2576 transgenic model of Alzheimer's disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-kappaB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.
Keywords: E-7869, Flurizan, Tarenflurbil, (R)-(-)-2-fluoro-alpha-methyl-4-biphenylacetic acid
Supplier: Cayman Chemical
Supplier-Nr: 70255-1


Application: Gamma secretase inhibitor
MW: 244.3 D
Formula: C15H13FO2
Purity: >99%
Format: Crystalline Solid

Database Information

CAS : 51543-40-9| Find alternatives

Handling & Safety

Storage: +20°C
Shipping: +20°C (International: +20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501
Our products are for laboratory research use only: Not for administration to humans!
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