PRIMA-1MET

Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 (Cay-63520) is a unique anti-oncogenic substance that re-activates the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1MET is a methylated derivative of PRIMA-1 that restores tumor-suppressor function to mutant p53 and induces cell death in various cancer cell lines. PRIMA-1MET can synergize with chemotherapeutic drugs to induce tumor cell apoptosis. At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance.Formal Name: 2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one. CAS Number: 5291-32-7. Synonyms: APR 246. Molecular Formula: C10H17NO3. Formula Weight: 199.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: O=C1C2CCN(CC2)C1(CO)COC. InChi Code: InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3. InChi Key: BGBNULCRKBVAKL-UHFFFAOYSA-N.