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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-15-1012-1 | 1 mg | - | - |
3 - 11 business days* |
102.00€
|
||
ABE-15-1012-2 | 2 mg | - | - |
3 - 11 business days* |
188.00€
|
MW: High molecular weight (>1.5kb). Toll-like receptor (TLR) 3 is an endosomal TLR that mediates... more
Product information "Poly(I).Poly(C) HMW"
MW: High molecular weight (>1.5kb). Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. Toll-like receptor 3 (TLR3), melanoma differentiation-associated gene 5 (MDA5), and retinoic acid-inducible gene-I (RIG-I), all sensors of double-stranded RNA (dsRNA) are potent inducers of antiviral activity. dsRNA sensor activation -e.g. by poly (I:C)- induces pro-inflammatory TNF-alpha and antiviral IFN-Beta, but can also enhance the expression of pro-apoptotic proteins. Recently, poly (I:C)-induced cell death recently gained considerable attention as a tool to study the 'Ripoptosome' or 'Necrosome' complex, a novel intracellular signaling complex, thought to induce regulated necrosis, also called 'Necroptosis'.
Supplier: | Abeomics |
Supplier-Nr: | 15-1012 |
Properties
Application: | FA, TLR3 ligand, antiviral response inducer |
Database Information
KEGG ID : | K05401 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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