Poly(I).Poly(C) HMW

Poly(I).Poly(C) HMW
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ABE-15-1012-1 1 mg - -

3 - 11 business days*

102.00€
ABE-15-1012-2 2 mg - -

3 - 11 business days*

188.00€
 
MW:  High molecular weight (>1.5kb). Toll-like receptor (TLR) 3 is an endosomal TLR that mediates... more
Product information "Poly(I).Poly(C) HMW"
MW:  High molecular weight (>1.5kb). Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. Toll-like receptor 3 (TLR3), melanoma differentiation-associated gene 5 (MDA5), and retinoic acid-inducible gene-I (RIG-I), all sensors of double-stranded RNA (dsRNA) are potent inducers of antiviral activity. dsRNA sensor activation -e.g. by poly (I:C)- induces pro-inflammatory TNF-alpha and antiviral IFN-Beta, but can also enhance the expression of pro-apoptotic proteins. Recently, poly (I:C)-induced cell death recently gained considerable attention as a tool to study the 'Ripoptosome' or 'Necrosome' complex, a novel intracellular signaling complex, thought to induce regulated necrosis, also called 'Necroptosis'.
Supplier: Abeomics
Supplier-Nr: 15-1012

Properties

Application: FA, TLR3 ligand, antiviral response inducer

Database Information

KEGG ID : K05401 | Matching products

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Poly(I).Poly(C) HMW"
Write a review
or to review a product.
Viewed