PNU 112455A

PNU 112455A is an inhibitor of cyclin-dependent kinase 2 (Cdk2) and Cdk5 (Ki = 2 µM for both). It inhibits hyperphosphorylation of tau and cell death induced by the synthetic glucocorticoid dexamethasone (Cay-11015) in PC12 rat adrenal medulla cells expressing human tau when used at concentrations of 1 and 10 µM.Formal Name: 4-[(6-amino-4-pyrimidinyl)amino]-benzenesulfonamide, monohydrochloride. CAS Number: 21886-12-4. Molecular Formula: C10H11N5O2S . HCl. Formula Weight: 301.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 221, 255, 304 nm. SMILES: O=S(N)(C1=CC=C(NC2=CC(N)=NC=N2)C=C1)=O.Cl. InChi Code: InChI=1S/C10H11N5O2S.ClH/c11-9-5-10(14-6-13-9)15-7-1-3-8(4-2-7)18(12,16)17,/h1-6H,(H2,12,16,17)(H3,11,13,14,15),1H. InChi Key: XBXQRCJKDCEQBS-UHFFFAOYSA-N.