PI3-Kinase alpha Inhibitor 2

PI3-Kinase alpha (PI3Kalpha) inhibitor 2 is an inhibitor of PI3K p110alpha (IC50 = 2 nM in an enzyme assay). It is selective for p110alpha over p110beta, p110gamma, and PI3K C2beta (IC50s = 16, 660, and 220 nM, respectively). It also inhibits mammalian target of rapamycin (mTOR, IC50 = 49 nM). PI3Kalpha inhibitor 2 inhibits proliferation in A375 melanoma cells with an IC50 value of 0.58 µM.Formal Name: 3-[4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl-phenol. CAS Number: 371943-05-4. Synonyms: PI3Kalpha Inhibitor 2, Phosphatidylinositol 3-Kinase alpha Inhibitor 2. Molecular Formula: C16H15N3O2S. Formula Weight: 313.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2) (1:3): 0.25mg/ml, DMSO: 25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 255, 299 nm. SMILES: Oc1cccc(c1)c1nc2ccsc2c(n1)N1CCOCC1. InChi Code: InChI=1S/C16H15N3O2S/c20-12-3-1-2-11(10-12)15-17-13-4-9-22-14(13)16(18-15)19-5-7-21-8-6-19/h1-4,9-10,20H,5-8H2. InChi Key: XXLAEKOWCYJOKK-UHFFFAOYSA-N.