PARG Inhibitor PDD00017273

PARG Inhibitor PDD00017273
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-CR1-3646-M001 1 mg -

approx. 1-3 business days

72.00€
AG-CR1-3646-M005 5 mg -

3 - 9 business days

198.00€
 
White to off-white solid. Soluble in DMSO, methanol or acetonitrile. Human poly(ADP-ribose)... more
Product information "PARG Inhibitor PDD00017273"
White to off-white solid. Soluble in DMSO, methanol or acetonitrile. Human poly(ADP-ribose) glycohydrolase (PARG) inhibitor for in vitro studies, Inhibits human recombinant PARG enzymes (IC50=26nM) and PARG in cell assays (IC50=37nM). Inactive against related glycohydrolases ARH3 and PARP1s (IC50>,30µ,M). Showed no cytotoxicity (IC50>,30µ,M), Poly(ADP ribose) glycohydrolase (PARG) is a critical component in the repair of single strand DNA breaks and therefore a target in cancer cells. PARG counteracts the function of the ARTD family of poly(ADP ribose) polymerases (known as PARPs) by efficiently catalysing the hydrolysis of O-glycosidic linkages of ADP-ribose polymer, thereby reversing the effects of PARPs.
Keywords: PARG Inhibitor Compound 4, 1-[(2,5-Dimethylpyrazol-3-yl)methyl]-N-(1-methylcyclopropyl)-3-[(2-methylthiazol-5-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide
Supplier-Nr: AG-CR1-3646-M001

Properties

Application: PARG inhibitor
MW: 514,6 D
Formula: C23H26N6O4S2
Purity: >98%
Format: Solid

Database Information

CAS : 1945950-21-9| Search using CAS
KEGG ID : K07759 | Search using KEGG ID

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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