PAOA

PAOA is a selective histone deacetylase (HDAC) inhibitor with IC50 values of 199 and 69 nM for HDAC1 and HDAC3, respectively. It is selective for HDAC1 and HDAC3, having IC50 values greater than 1.59 µM for HDAC2, 4, 5, 7, and 8 in a cell-free enzyme assay. In vitro, PAOA induces histone H3 and H4 hyperacetylation. PAOA improves the metabolic deficit exhibited by murine striatal cells isolated from HdhQ111 knock-in mice in a dose-dependent manner and reduces eye neurodegeneration in a D. melanogaster model of Huntington's disease. In vivo, PAOA prevents formation of Huntingtin (Htt) protein aggregates in the brain and reduces the cognitive deficits in the N171-82Q mouse model of Huntington's disease.Formal Name: N1-(2-aminophenyl)-N7-phenyl-heptanediamide. CAS Number: 537034-15-4. Synonyms: Histone Deacetylase Inhibitor IV. Molecular Formula: C19H23N3O2. Formula Weight: 325.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 30 mg/ml. lambdamax: 242, 288 nm. SMILES: NC1=C(NC(CCCCCC(NC2=CC=CC=C2)=O)=O)C=CC=C1. InChi Code: InChI=1S/C19H23N3O2/c20-16-11-7-8-12-17(16)22-19(24)14-6-2-5-13-18(23)21-15-9-3-1-4-10-15/h1,3-4,7-12H,2,5-6,13-14,20H2,(H,21,23)(H,22,24). InChi Key: ZAIULUYKQLVQFH-UHFFFAOYSA-N.