OTS964 (hydrochloride)

OTS964 is an inhibitor of lymphokine-activated killer T cell-originated protein kinase (TOPK, IC50 = 28 nM). It specifically blocks cytokinesis, leading to apoptosis, in a broad range of cancer cells. OTS964 induces apoptosis of human lung cancer cells in mouse xenografts.Formal Name: 9-[4-[(1R)-2-(dimethylamino)-1-methylethyl]phenyl]-8-hydroxy-6-methyl-thieno[2,3-c]quinolin-4(5H)-one, monohydrochloride. CAS Number: 1338545-07-5. Molecular Formula: C23H24N2O2S . HCl. Formula Weight: 429.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.25 mg/ml. lambdamax: 220, 290, 351 nm. SMILES: CC1=C2C(C(C=CS3)=C3C(N2)=O)=C(C4=CC=C([C@@H](C)CN(C)C)C=C4)C(O)=C1.Cl. InChi Code: InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17-9-10-28-22(17)23(27)24-21(13)20,/h5-11,14,26H,12H2,1-4H3,(H,24,27),1H/t14-,/m0./s1. InChi Key: YHPWOYBWUWSJDW-UQKRIMTDSA-N.