Obatoclax (mesylate)

Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd = ~500 nM). It prevents the interaction of these pro-survival proteins with Bax or Bak, thereby inducing apoptosis with up-regulation of Bim, induced cytochrome c release, and activation of caspase-3. Obatoclax also induces autophagy in mouse embryo fibroblasts and in HeLa cells. This compound inhibits the growth of cancer cell lines and primary cancer isolates.Formal Name: 2-[2-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole, monomethanesulfonate. CAS Number: 803712-79-0. Synonyms: GX15-070. Molecular Formula: C20H19N3O . CH3SO3H. Formula Weight: 413.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 11 mg/ml, Ethanol: 2 mg/ml. lambdamax: 287, 314, 352, 546 nm. SMILES: CC(C=C(C)N1)=C1/C=C2C(OC)=CC(C(N3)=CC4=C3C=CC=C4)=N/2.CS(=O)(O)=O. InChi Code: InChI=1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23-19)17-9-14-6-4-5-7-15(14)22-17,1-5(2,3)4/h4-11,21-22H,1-3H3,1H3,(H,2,3,4)/b19-10-,. InChi Key: ZFKXDVMHNXPEIY-PEZBNFGJSA-N.