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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| BPS-27044 | 5 mg | - | - |
3 - 15 business days* |
255.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Obatoclax, also known as GX15-070, is a novel Bcl-2 homology domain-3 (BH3) mimetic. It occupies... more
Product information "Obatoclax"
Obatoclax, also known as GX15-070, is a novel Bcl-2 homology domain-3 (BH3) mimetic. It occupies a hydrophobic cleft within the BH3 binding groove of Bcl-2, antagonizing Bcl-2 and thus inducing apoptosis. Obatoclax inhibited primary acute myeloid leukemia (AML) progenitor cell proliferation with an average IC50 of 0.18 ± 0.07 µM, and it potently induced apoptosis in primary AML cells with an average IC50 of 3.6 ± 1.2 µM. Obatoclax overcomes Bcl-2-, Bcl-xL-, Bcl-w-, and Mcl-1-mediated resistance to BAX or BAK and to the proteasome inhibitor bortezomib.
| Keywords: | GX15-070, Obatoclax mesylate, |
| Supplier: | BPS Bioscience |
| Supplier-Nr: | 27044 |
Properties
| Application: | BH3 mimetic |
| MW: | 413.5 D |
| Formula: | C20H19N3O . CH4SO3 |
Database Information
| KEGG ID : | K02539 | Matching products |
Handling & Safety
| Storage: | -20°C (Store aqueous sol. one day max) |
| Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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