NSC 632839

NSC 632839
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay16893-1 1 mg -

6 - 10 business days*

43.00€
Cay16893-5 5 mg -

6 - 10 business days*

125.00€
Cay16893-25 25 mg -

6 - 10 business days*

308.00€
Cay16893-50 50 mg -

6 - 10 business days*

409.00€
 
Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes... more
Product information "NSC 632839"
Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 µM, respectively. It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 µM in cells sensitized by E1A, an adenoviral oncogene).Formal Name: 3,5-bis[(4-methylphenyl)methylene]-4-piperidinone, monohydrochloride. CAS Number: 157654-67-6. Synonyms: F6, Ubiquitin Isopeptidase Inhibitor II. Molecular Formula: C21H21NO . HCl. Formula Weight: 339.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 240, 345 nm. SMILES: CC1=CC=C(/C=C2C(/C(CNC\2)=C\C3=CC=C(C)C=C3)=O)C=C1.Cl. InChi Code: InChI=1S/C21H21NO.ClH/c1-15-3-7-17(8-4-15)11-19-13-22-14-20(21(19)23)12-18-9-5-16(2)6-10-18,/h3-12,22H,13-14H2,1-2H3,1H/b19-11-,20-12-,. InChi Key: ZOKZLTXPTLIWOJ-GRVJEYRUSA-N.
Keywords: F6, Ubiquitin Isopeptidase Inhibitor II, 3,5-bis[(4-methylphenyl)methylene]-4-piperidinone, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 16893

Properties

Application: USP2 / USP7 / SENP2 inhibitor
MW: 339.9 D
Formula: C21H21NO . HCl
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 157654-67-6| Matching products
KEGG ID : K03345 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H319
P Phrases: P264, P280, P305+P351+P338, P337+P313
Caution
Our products are for laboratory research use only: Not for administration to humans!
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