Niclosamide (ethanolamine salt)

Niclosamide (ethanolamine salt)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17118-100 100 mg -

5 - 10 business days*

82.00€
Cay17118-250 250 mg -

5 - 10 business days*

123.00€
Cay17118-500 500 mg -

5 - 10 business days*

204.00€
Cay17118-1 1 g -

5 - 10 business days*

367.00€
 
Niclosamide is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and... more
Product information "Niclosamide (ethanolamine salt)"
Niclosamide is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. It inhibits STAT3 (IC50 = 0.25 µM) and stimulates autophagy by reversibly inhibiting mammalian target of rapamycin complex 1 (mTORC1) signaling. It completely inhibits phosphorylation of ribosomal S6 kinases (S6K) when used at a concentration of 3 µM. Niclosamide (1 µM) induces mitochondrial uncoupling, decreasing cellular ATP concentrations and increasing the ratio of ADP to ATP in HepG2 cells, and activates AMP-activated protein kinase (AMPK) in NIH3T3 cells. It also increases lipid oxidation by 5-fold in HepG2 cells. It prevents high-fat diet-induced hepatic steatosis and insulin resistance and improves glycemic control in db/db mice when administered at a dose of at 125 mg/kg per day. Niclosamide also inhibits proliferation and colony formation of DU145 prostate cancer cells, which have constitutively active STAT3 (IC50s = 0.7 and 0.1 µM, respectively). Formal Name: 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamide compd. with 2-aminoethanol. CAS Number: 1420-04-8. Synonyms: BAY-73, BAY-6076, Bayluscide, HL 2448. Molecular Formula: C13H8Cl2N2O4 . C2H7NO. Formula Weight: 388.2. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL, Ethanol: 0.25 mg/mL. lambdamax: 210, 235, 331 nm. SMILES: OC1=C(C(NC2=CC=C([N+]([O-])=O)C=C2Cl)=O)C=C(Cl)C=C1.NCCO. InChi Code: InChI=1S/C13H8Cl2N2O4.C2H7NO/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15,3-1-2-4/h1-6,18H,(H,16,19),4H,1-3H2. InChi Key: XYCDHXSQODHSLG-UHFFFAOYSA-N.
Keywords: BAY-6076, BAY-73, Bayluscide, HL 2448, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamide compd. with 2-aminoethanol
Supplier: Cayman Chemical
Supplier-Nr: 17118

Properties

Application: Anthelmintic
MW: 388.2 D
Formula: C13H8Cl2N2O4 . C2H7NO
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 1420-04-8| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H319, H400, H410
P Phrases: P264, P273, P280, P305+351+338, P337+313, P391, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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