Nepsilon-(1-Carboxymethyl)-L-lysine-d3

Nepsilon-(1-Carboxymethyl)-L-lysine-d3 (CML-d3) is intended for use as an internal standard for the quantification of CML (Cay-16483) by GC- or LC-MS. CML is an advanced glycation end product (AGE), produced by the oxidative modification of glycated proteins during oxidative stress. Levels of CML increase with aging and during diabetes, cancer, vascular disease, and other pathologies marked by oxidative stress. CML activates the membrane-bound receptor for AGEs (RAGE), triggering signaling through MAPKs and NF-kappaB, whereas truncation of RAGE produces a soluble protein that binds CML and reduces signaling.Formal Name: N6-(carboxymethyl)-L-lysine-2,6,6-d3. CAS Number: 2699607-49-1. Synonyms: CML-d3. Molecular Formula: C8H13D3N2O4. Formula Weight: 207.2. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: OC(CNC([2H])([2H])CCC[C@@](N)([2H])C(O)=O)=O. InChi Code: InChI=1S/C8H16N2O4/c9-6(8(13)14)3-1-2-4-10-5-7(11)12/h6,10H,1-5,9H2,(H,11,12)(H,13,14)/t6-/m0/s1/i4D2,6D. InChi Key: NUXSIDPKKIEIMI-SASOZDAZSA-N.