Navtemadlin

Item number	Size	Delivery time	Price
TGM-TQ0127-1mg	1 mg	7 - 10 business days*	64.00€
TGM-TQ0127-2mg	2 mg	7 - 10 business days*	89.00€
TGM-TQ0127-5mg	5 mg	7 - 10 business days*	138.00€
TGM-TQ0127-10mg	10 mg	7 - 10 business days*	215.00€
TGM-TQ0127-25mg	25 mg	7 - 10 business days*	437.00€
TGM-TQ0127-50mg	50 mg	7 - 10 business days*	645.00€
TGM-TQ0127-100mg	100 mg	7 - 10 business days*	921.00€

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Description: Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of... more

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Product information "Navtemadlin"

Description: Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM. Target: E1/E2/E3 Enzyme, Mdm2. Smiles: CC(C)[C@@H](CS(=O)(=O)C(C)C)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1. References: Canon J, et al. The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents. Mol Cancer Ther. 2015 Mar,14(3):649-58.

Keywords:	AMG232, CS-1300
Supplier:	TargetMol
Supplier-Nr:	TQ0127

Properties

Application:	Targets E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27] (MDM2)
MW:	568.55 D
Formula:	C28H35Cl2NO5S

Database Information

CAS :	1352066-68-2\| Matching products
KEGG ID :	K06643 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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