LY2835219 (methanesulfonate)

LY2835219 (methanesulfonate)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay17740-1 1 mg -

6 - 10 business days*

60.00€
Cay17740-5 5 mg -

6 - 10 business days*

85.00€
Cay17740-10 10 mg -

6 - 10 business days*

125.00€
 
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6... more
Product information "LY2835219 (methanesulfonate)"
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.Formal Name: N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine, methanesulfonate. CAS Number: 1231930-82-7. Synonyms: Abemaciclib. Molecular Formula: C27H32F2N8 . CH4O3S. Formula Weight: 602.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 245, 272, 299 nm. SMILES: CCN1CCN(CC2=CC=C(NC3=NC=C(F)C(C4=CC(F)=C(N=C(C)N5C(C)C)C5=C4)=N3)N=C2)CC1.OS(C)(=O)=O. InChi Code: InChI=1S/C27H32F2N8.CH4O3S/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26,1-5(2,3)4/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34),1H3,(H,2,3,4). InChi Key: NCJPFQPEVDHJAZ-UHFFFAOYSA-N.
Keywords: Abemaciclib, N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine, methanesulfonate
Supplier: Cayman Chemical
Supplier-Nr: 17740

Properties

Application: CDK4 / CDK6 inhibitor
MW: 602.7 D
Formula: C27H32F2N8 . CH4O3S
Purity: >95%
Format: Crystalline Solid

Database Information

CAS : 1231930-82-7| Matching products
KEGG ID : K02089 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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