LY2835219

LY2835219
Item number Size Datasheet Manual SDS Delivery time Quantity Price
CDX-L0303-M100 100 mg - -

3 - 9 business days*

230.00€
CDX-L0303-M250 250 mg - -

3 - 9 business days*

428.00€
 
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6... more
Product information "LY2835219"
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds. Product References: (1) M.A. Dickson, Clin. Cancer Res. 20, 3379 (2014) , (2) L.M. Gelbert, et al., Invest. New. Drugs 32, 825 (2014) , (3) S.C. Tate, et al., Clin. Cancer Res. 20, 3763 (2014) Appearance: Off-white powder. Solubility: Soluble in DMSO (20mg/ml) or water (30mg/ml). Identity: Determined by 1H-NMR. InChi Key: NCJPFQPEVDHJAZ-UHFFFAOYSA-N Smiles: CCN(CC1)CCN1CC2=CC=C(NC3=NC=C(F)C(C4=CC(F)=C(N=C(C)N5C(C)C)C5=C4)=N3)N=C2.CS(=O)(O)=O
Keywords: LY2835219 methanesulfonate, Abemaciclib methanesulfonate, Abemaciclib mesylate, Bemaciclib
Supplier: Chemodex
Supplier-Nr: L0303

Properties

Application: CDK4 / CDK6 dual inhibitor
MW: 602.7 D
Formula: C27H32F2N8 . CH4O3S
Purity: >99%
Format: Solid

Database Information

CAS : 1231930-82-7| Matching products
KEGG ID : K02089 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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