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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
CDX-L0303-M100 | 100 mg | - | - |
3 - 9 business days* |
230.00€
|
||
CDX-L0303-M250 | 250 mg | - | - |
3 - 9 business days* |
428.00€
|
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6... more
Product information "LY2835219"
LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively). Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds. Product References: (1) M.A. Dickson, Clin. Cancer Res. 20, 3379 (2014) , (2) L.M. Gelbert, et al., Invest. New. Drugs 32, 825 (2014) , (3) S.C. Tate, et al., Clin. Cancer Res. 20, 3763 (2014) Appearance: Off-white powder. Solubility: Soluble in DMSO (20mg/ml) or water (30mg/ml). Identity: Determined by 1H-NMR. InChi Key: NCJPFQPEVDHJAZ-UHFFFAOYSA-N Smiles: CCN(CC1)CCN1CC2=CC=C(NC3=NC=C(F)C(C4=CC(F)=C(N=C(C)N5C(C)C)C5=C4)=N3)N=C2.CS(=O)(O)=O
Keywords: | LY2835219 methanesulfonate, Abemaciclib methanesulfonate, Abemaciclib mesylate, Bemaciclib |
Supplier: | Chemodex |
Supplier-Nr: | L0303 |
Properties
Application: | CDK4 / CDK6 dual inhibitor |
MW: | 602.7 D |
Formula: | C27H32F2N8 . CH4O3S |
Purity: | >99% |
Format: | Solid |
Database Information
CAS : | 1231930-82-7| Matching products |
KEGG ID : | K02089 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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