LUF6283

LUF6283 is a partial agonist of GPR109A/HCA2 G protein-coupled receptors (Ki = 0.55 µM in a radioligand binding assay). It stimulates [35S]-GTPgammaS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 µM, respectively). In vivo, LUF6283 (400 mg/kg per day) reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice.Formal Name: 5-butyl-1H-pyrazole-3-carboxylic acid. CAS Number: 92933-48-7. Molecular Formula: C8H12N2O2. Formula Weight: 168.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 16 mg/mL, Ethanol: 16 mg/mL. lambdamax: 218 nm. SMILES: O=C(O)C1=NNC(CCCC)=C1. InChi Code: InChI=1S/C8H12N2O2/c1-2-3-4-6-5-7(8(11)12)10-9-6/h5H,2-4H2,1H3,(H,9,10)(H,11,12). InChi Key: ZJTXSGLJNBAMJS-UHFFFAOYSA-N.