Lonidamine

Lonidamine
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14640-5 5 mg -

6 - 10 business days*

66.00€
Cay14640-10 10 mg -

6 - 10 business days*

104.00€
Cay14640-50 50 mg -

6 - 10 business days*

225.00€
Cay14640-100 100 mg -

6 - 10 business days*

383.00€
 
Lonidamine, originally identified as a potent antispermatogenic agent, inhibits glycolysis though... more
Product information "Lonidamine"
Lonidamine, originally identified as a potent antispermatogenic agent, inhibits glycolysis though the inactivation of mitochondria-bound hexokinase. It can decrease oxygen consumption as well as aerobic and anaerobic glycolysis in Ehrlich ascites tumor cells with IC50 values of 90 and 45 µM, respectively. A role for lonidamine as a therapeutic for mitochondrial dysfunction has been explored in various disorders, including cancer, neurodegenerative and neuromuscular diseases, obesity, and diabetes.Formal Name: 1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid. CAS Number: 50264-69-2. Synonyms: AF 1890, DICA, Diclondazolic Acid. Molecular Formula: C15H10Cl2N2O2. Formula Weight: 321.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 1.7 mg/ml. lambdamax: 298 nm. SMILES: OC(C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C3=CC=CC=C31)=O. InChi Code: InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21). InChi Key: WDRYRZXSPDWGEB-UHFFFAOYSA-N.
Keywords: AF 1890, DICA, Diclondazolic Acid, 1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid
Supplier: Cayman Chemical
Supplier-Nr: 14640

Properties

Application: Anticancer agent, HK1 inhibitor
MW: 321.2 D
Formula: C15H10Cl2N2O2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 50264-69-2| Matching products
KEGG ID : K00844 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H351, H360
P Phrases: P201, P202, P264, P270, P280, P301+310, P308+313, P330, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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