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Bacterial pathogens require the conserved membrane histidine sensor kinase (QseC) to detect both host-derived adrenergic signals and the bacterial autoinducer-3 (AI-3), thus activating a signaling cascade that induces virulence gene expression. LED209 is a potent QseC inhibitor that blocks both norepinephrine- and epinephrine-triggered QseC-dependent virulence gene expression at 5 pM in vitro. While LED209 inhibits virulence of enterohemorrhagic E. coli, S. typhimurium, and F. tularensis, it does not inhibit pathogen growth, a highly desirable feature of antimicrobial agents to prevent drug resistance. Formal Name: N-phenyl-4-[[(phenylamino)thioxomethyl]amino]-benzenesulfonamide. CAS Number: 245342-14-7. Molecular Formula: C19H17N3O2S2. Formula Weight: 383.5. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.15 mg/ml. lambdamax: 295 nm. SMILES: S=C(Nc1ccc(cc1)S(=O)(=O)Nc1ccccc1)Nc1ccccc1. InChi Code: InChI=1S/C19H17N3O2S2/c23-26(24,22-17-9-5-2-6-10-17)18-13-11-16(12-14-18)21-19(25)20-15-7-3-1-4-8-15/h1-14,22H,(H2,20,21,25). InChi Key: HNDRSTUKPCLQLT-UHFFFAOYSA-N.