Latrunculin B

Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010631-500 500 µg -

6 - 10 business days*

225.00€
Cay10010631-1 1 mg -

6 - 10 business days*

294.00€
 
The latrunculins are commonly used to experimentally disrupt the actin cytoskeleton of cells.... more
Product information "Latrunculin B"
The latrunculins are commonly used to experimentally disrupt the actin cytoskeleton of cells. Latrunculin B causes concentration-dependent changes in cell shape and actin organization. It sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro and in cells (Kd = 60 nM). The short-term effects of latrunculin B are comparable to those of latrunculin A, although latrunculin B is slightly less potent. However, latrunculin B is gradually inactivated by serum so that induced changes are transient in the continued presence of the compound. For this reason, latrunculin B may have fewer unwanted effects than latrunculin A and may be preferred for short-term studies.Formal Name: 4R-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone. CAS Number: 76343-94-7. Molecular Formula: C20H29NO5S. Formula Weight: 395.5. Purity: >97%. Formulation: (Request formulation change), A film. Solubility: DMSO: 25 mg/ml, Ethanol: 25 mg/ml. SMILES: C/C(CC/C=C\[C@@H](C)CC[C@@H]1C[C@@H]2C[C@@]([C@@]3([H])NC(SC3)=O)(O)O1)=C/C(O2)=O. InChi Code: InChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1. InChi Key: NSHPHXHGRHSMIK-JRIKCGFMSA-N. Origin: Animal/Latrunculia magnifica.
Keywords: 4R-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone
Supplier: Cayman Chemical
Supplier-Nr: 10010631

Properties

Application: Actin polymerization inhibitor
MW: 395.5 D
Formula: C20H29NO5S
Purity: >97%
Format: Solution

Database Information

CAS : 76343-94-7| Matching products
KEGG ID : K05692 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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