Latrunculin A

Latrunculin A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010630-25 25 µg -

6 - 10 business days*

66.00€
Cay10010630-50 50 µg -

6 - 10 business days*

123.00€
Cay10010630-100 100 µg -

6 - 10 business days*

180.00€
 
Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in... more
Product information "Latrunculin A"
Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro (Kd = 0.2 µM) and in cells (0.5 µM, 30 min).{ Latrunculin A (1-10 µM) causes depolymerization of tumor cell cytoskeleton within ten minutes. Overnight treatment of cells with latrunculin A (10 µM) strongly suppresses actin synthesis. Prolonged cell treatment blocks dexamethasone-induced changes in actin cytoskeleton with no effect on cell viability.Formal Name: (4R)-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone. CAS Number: 76343-93-6. Synonyms: NSC 613011. Molecular Formula: C22H31NO5S. Formula Weight: 421.6. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: 25 mg/ml, Ethanol: 25 mg/ml. SMILES: C/C(CC/C=C/C=C\[C@@H](C)CC[C@@H]1C[C@@H]2C[C@@]([C@H]3NC(SC3)=O)(O)O1)=C/C(O2)=O. InChi Code: InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1. InChi Key: DDVBPZROPPMBLW-IZGXTMSKSA-N.
Keywords: NSC 613011, (4R)-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone
Supplier: Cayman Chemical
Supplier-Nr: 10010630

Properties

Application: Actin polymerization inhibitor
MW: 421.6 D
Formula: C22H31NO5S
Purity: >95%
Format: Solution

Database Information

CAS : 76343-93-6| Matching products
KEGG ID : K05692 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H319, H333
P Phrases: P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P304+312, P305+351+338, P337+313, P370+378, P403+235, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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