L-Buthionine-(S,R)-Sulfoximine

L-Buthionine-(S,R)-Sulfoximine
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14484-250 250 mg -

6 - 10 business days*

82.00€
Cay14484-500 500 mg -

6 - 10 business days*

155.00€
Cay14484-1 1 g -

6 - 10 business days*

293.00€
 
L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase... more
Product information "L-Buthionine-(S,R)-Sulfoximine"
L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase (Ki <100 µM), the rate-limiting enzyme for L-glutathione (GSH) synthesis, that induces oxidative stress in cells by depleting GSH. Administration of L-buthionine-(S,R)-sulfoximine leads to decreased GSH levels in virtually all tissues and is associated with tissue damage and apoptosis. Whereas elevated glutathione levels are associated with tumor cell resistance, L-buthionine-(S,R)-sulfoximine has been shown to enhance the toxicity of various chemotherapeutic agents in drug-resistant tumors. Formal Name: 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid. CAS Number: 83730-53-4. Synonyms: BSO, NSC 326231. Molecular Formula: C8H18N2O3S. Formula Weight: 222.3. Purity: >98%. Formulation: A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES: O=S(CCCC)(CC[C@H](N)C(O)=O)=N. InChi Code: InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1. InChi Key: KJQFBVYMGADDTQ-CVSPRKDYSA-N.
Keywords: BSO, NSC 326231, 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid
Supplier: Cayman Chemical
Supplier-Nr: 14484

Properties

Application: Oxidative stress inducer
MW: 222.3 D
Formula: C8H18N2O3S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 83730-53-4| Find alternatives
KEGG ID : K11204 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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