L-Buthionine-(S,R)-Sulfoximine

L-Buthionine-(S,R)-Sulfoximine
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay14484-250 250 mg -

6 - 10 business days*

109.00€
Cay14484-500 500 mg -

6 - 10 business days*

204.00€
Cay14484-1 1 g -

6 - 10 business days*

383.00€
 
L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase... more
Product information "L-Buthionine-(S,R)-Sulfoximine"
L-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase (Ki = 25 µM). It inhibits the proliferation of ZAZ and M14 melanoma cells, as well as A2780 ovarian and MCF-7 breast cancer cells (IC50s = 4.9, 18, 8.5, and 26.5 µM, respectively). L-Buthionine-(S,R)-sulfoximine (100µM) induces ferroptosis in A172 and T98G glioblastoma cells. It increases reactive oxygen species (ROS) levels in HeLa cells when used at a concentration of 10 µM. L-Buthionine-(S,R)-sulfoximine (1 mM), in combination with methylglyoxal, induces apoptosis of bovine aortic endothelial cells (BAECs). It increases the number of eye spots in the retinal pigment epithelium, an indicator of DNA deletions, in mouse pups when administered to pregnant dams at concentrations of 2 and 20 mM in the drinking water. L-Buthionine-(S,R)-sulfoximine decreases cysteine and glutathione (GSH) levels in fetal mice when administered to pregnant dams.Formal Name: 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid. CAS Number: 83730-53-4. Synonyms: BSO, NSC 326231. Molecular Formula: C8H18N2O3S. Formula Weight: 222.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 5 mg/ml. SMILES: O=S(CCCC)(CC[C@H](N)C(O)=O)=N. InChi Code: InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1. InChi Key: KJQFBVYMGADDTQ-CVSPRKDYSA-N.
Keywords: BSO, NSC 326231, 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid
Supplier: Cayman Chemical
Supplier-Nr: 14484

Properties

Application: Oxidative stress inducer
MW: 222.3 D
Formula: C8H18N2O3S
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 83730-53-4| Matching products
KEGG ID : K11204 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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