K777 [K11777]

K777 [K11777]
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-CR1-0158-M001 1 mg -

3 - 9 business days*

44.00€
AG-CR1-0158-M005 5 mg -

3 - 9 business days*

176.00€
 
Solid. Soluble in DMSO. Insoluble in water. Potent, irreversible cysteine protease inhibitor,... more
Product information "K777 [K11777]"
Solid. Soluble in DMSO. Insoluble in water. Potent, irreversible cysteine protease inhibitor, Broad-range cathepsin inhibitor (for all known cathepsins) useful for inflammasome inhibition. Inhibits cathepsins B, L, S, C, V, K and papain in cell-free assays. Inhibits cathepsin X as well, Suppresses particle-induced NLRP3 activation and IL-1beta secretion more efficiently than Ca074Me (cathepsin B inhibitor), which in contrast suppresses nigericin-induced IL-1beta secretion, Selectively inhibits particle-induced cell death but not nigericin- or sAdT-induced cell death, Potent and selective CCR4 antagonist, Potent cysteine protease cruzain (cruzipain) inhibitor. Active against Trypanosoma cruzi the causative agent of Chagas' disease, a parasitic infection which is a leading cause of heart disease, Antiparasitic agent with anti-trypanosomal , anti-leishmanial, anti-schistosomiasis, anti-amebiasis (EhCP1 (E. Histolytica cysteine proteinase 1)), anti-anthelmintic (hookworm first-stage larvae) and anti-cryptosporidial activity, Shown to have antiviral activity by targeting cathepsin-mediated cell entry.
Keywords: K-777, K-11777, N-Pip-F-hF-VS Phenyl, N-Pip-phenylalanine-homophenylalanine-vinyl sulfone phenyl, N-Methyl-piperazinyl-L-phenylalanyl-L-homophenylalanyl-vinyl sulfone
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-CR1-0158

Properties

Application: Potent irreversible cysteine protease inhibitor
MW: 574,7 D
Formula: C32H38N4O4S
Purity: >98%
Format: Solid

Database Information

CAS : 233277-99-1| Matching products
KEGG ID : K01363 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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