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Indirubin is a bisindole isomer of indigo, naturally sourced from Indigo naturalis. Indirubin exhibits anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. In vivo, indirubin decreases levels of IgE and production of inflammatory cytokines, decreasing overall inflammation as well as skin lesion thickness and hyperkeratosis. In vitro, indirubin downregulates expression of CDC25B and inhibits EGFR and CDKs. In leukemia cells, this compound inhibits expression of IAP1, IAP2, Bcl-2, Bcl-xL, TRAF1, cyclin D1, c-Myc, COX-2, and MMP-9. In endothelial cells, indirubin inhibits cell migration, tube formation, and survival, additionally, it suppresses VEGFR2-mediated JAK/STAT signaling. Indirubin also inhibits growth of prostate tumors in animal models.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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